The immediate short term goal of the CBID is to provide the necessary mentor support and infrastructure to ensure the success of junior investigators in acquiring NIH funding. The long term goal is to create a center that encourages basic research scientists to discover Chemical Biology of Infectious Disease and solution.
Assisting these investigators in guiding the progress of the Center are Internal Advisory Board (IAB) and the External Advisory Committee (EAC). The IAB reviews the activities of the CBID twice a year and make recommendations to the PI and Co-I for changes in the management and focus of the Program. The EAC meets twice a year, once by teleconference and once in a face-to-face meeting at the University of Kansas. During the latter meeting, members review the structure, function and scientific accomplishments of the program sponsored by CBID.
Three specific aims guide the research at the Center:
- Specific Aim 1: Provide a world-class environment, appropriately administered and staffed, to provide researchers access to key techniques relevant to the chemical biology of infectious disease. This aim will be accomplished through the effective functions and successful activities of an administrative core and three scientific cores facilities.
- Specific Aim 2: Support and enable junior faculty to build successful research programs through active mentorship, access to appropriate resources, and funding of meritorious programs. This will entail both the recruitment of investigators that have already formulated suitable projects (as ascertained through rigorous peer review) identification and the identification and mentoring of scientists who aspire to such projects in the near future.
- Specific Aim 3: Enhance infectious disease research throughout the regional scientific community by the recruitment of outstanding junior faculty, establishment of seminar series and other opportunities for scientific enrichment, and by providing core facility access to all interested researchers. This specific aim will build upon numerous commitments that the University of Kansas and partner institutions have already made to biomedical research in general and infectious disease biology in particular.
In order to support and encourage these types of interactions, the Center comprises three core facilities in addition to the Administrative Core. These are:
- The Infectious Disease Assay Development Core (IDAD) for assay development and high throughput screening technologies for identifying chemical probes against infectious disease targets,
- The Computational Chemical Biology Core (CCB) for structure and ligand based drug discovery, protein modeling, and chemoinformatics.
- The Synthetic Chemical Biology Core (SCB) for the synthesis of novel and commercially unavailable small molecules, fluorescent molecules, and peptides.
The following projects have been chosen based on their relevance to the theme of the proposal and the credentials of the young investigators:
Current Research Projects
- Synthetic Antibody Mimics as Antimalarial Agents, Mark P. Farrell, Medicinal Chemistry, University of Kansas
- Developing chemical inhibitors of essential ICP0 functions in Herpes Viruses, Maria Kalamvoki, Microbiology, Molecular Biology, and Genetics, University of Kansas Medical Center
- Chemical Inhibition of Legionella Pneumophila Metaeffector Function, Stephanie Shames, Biology, Kansas State University
Current Pilot Projects
- On again, off again: Is pH a criticial factor in pathogen killing?, Brian D. Ackley, Molecular Biosciences, University of Kansas
- Chemical biology studies of malleilactone, a small-molecule toxin produced by Burkholderia pseudomallei, Josephine R. Chandler, Molecular Biosciences, University of Kansas
- Bacterial glycosyltransferase inhibitors as anti-virulence compounds, Philip R. Hardwidge, Diagnostic Medicine/Pathobiology, Kansas State University
- Small Molecule Inhibitors of Bacterial Sruface Lipoprotein Secretion
, Wolfram R. Zückert, Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center