The immediate short term goal of the CBID is to provide the necessary mentor support and infrastructure to ensure the success of junior investigators in acquiring NIH funding. The long term goal is to create a center that encourages basic research scientists to discover Chemical Biology of Infectious Disease and solution.
Assisting these investigators in guiding the progress of the Center are Internal Advisory Board (IAB) and the External Advisory Committee (EAC). The IAB reviews the activities of the CBID twice a year and make recommendations to the PI and Co-I for changes in the management and focus of the Program. The EAC meets twice a year, once by teleconference and once in a face-to-face meeting at the University of Kansas. During the latter meeting, members review the structure, function and scientific accomplishments of the program sponsored by CBID.
Three specific aims guide the research at the Center:
- Specific Aim 1: Provide a world-class environment, appropriately administered and staffed, to provide researchers access to key techniques relevant to the chemical biology of infectious disease. This aim will be accomplished through the effective functions and successful activities of an administrative core and three scientific cores facilities.
- Specific Aim 2: Support and enable junior faculty to build successful research programs through active mentorship, access to appropriate resources, and funding of meritorious programs. This will entail both the recruitment of investigators that have already formulated suitable projects (as ascertained through rigorous peer review) identification and the identification and mentoring of scientists who aspire to such projects in the near future.
- Specific Aim 3: Enhance infectious disease research throughout the regional scientific community by the recruitment of outstanding junior faculty, establishment of seminar series and other opportunities for scientific enrichment, and by providing core facility access to all interested researchers. This specific aim will build upon numerous commitments that the University of Kansas and partner institutions have already made to biomedical research in general and infectious disease biology in particular.
In order to support and encourage these types of interactions, the Center comprises three core facilities in addition to the Administrative Core. These are:
- The Infectious Disease Assay Development Core (IDAD) for assay development and high throughput screening technologies for identifying chemical probes against infectious disease targets,
- The Computational Chemical Biology Core (CCB) for structure and ligand based drug discovery, protein modeling, and chemoinformatics.
- The Synthetic Chemical Biology Core (SCB) for the synthesis of novel and commercially unavailable small molecules, fluorescent molecules, and peptides.
The following projects have been chosen based on their relevance to the theme of the proposal and the credentials of the young investigators:
Current Research Projects
- Synthetic Antibody Mimics as Antimalarial Agents, Mark P. Farrell, Medicinal Chemistry, University of Kansas
- Deciphering the distinct roles of macrodomain ADP-ribose binding and hydrolysis in coronavirus replication, Anthony Fehr, Molecular Biosciences, University of Kansas
Current Pilot Projects
- Illuminating Old Catalysts for the Synthesis of Anti-Infective HIV Peptides, Steven Bloom, Medicinal Chemistry, University of Kansas
- Synthetic chemistry elaboration of fragments targeting the bacterial type III secretion, Zarko Boskovic, Medicinal Chemistry, University of Kansas
- Phage-protein based removal of pathogenic non-tuberculous Mycobacterium from drinking water, Justin Hutchison, Civil, Environmental and Architectural Engineering, University of Kansas
- First Enantioselective Syntheses of Bactobolins A, B, and Analogue Antiobiotics
, Shyam Sathyamoorthi, Medicinal Chemistry, University of Kansas