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Chemical Biology of Infectious Disease

The Chemical Biology of Infectious Disease is an NIH Center of Biomedical Research Excellence (COBRE) focused on chemical biology.


Researcher in a laboratory looking into a microscope

Our Goals

The goal of the CBID is to provide the necessary mentor support and infrastructure to ensure the success of junior investigators. and to create a center that encourages basic research scientists to discover Chemical Biology of Infectious Disease.

What We Do

Chemical biology is the focus of our efforts because it entails the discovery of chemical entities able to modulate pathways related to infectious processes. Such work can lead to an increase in biological understanding and the identification of novel targets for chemical intervention. Appropriate validation of such targets in advanced model systems, including animals, along with the pharmaceutical development of chemical series, can in turn provide leads for downstream drug discovery efforts.

Our CBID Center will strengthen infrastructure and enable scientists and biomedical research in the State of Kansas. The center capitalizes on existing strengths and resources, including some that have resulted from previous CoBRE efforts in cancer chemotherapy, high-throughput screening, medicinal chemistry, and proteomics, while addressing critical gaps that have so far limited the ability of researchers at the University of Kansas (KU) and associated institutions to apply these tools to the study of infectious disease targets.

The CBID is led by Principal Investigator, P. Scott Hefty, Professor of Molecular Biosciences. Dr. Hefty is a highly experienced molecular biologist and effective scientific administrator. He is joined by Jon Tunge, Professor of Chemistry, as co-investigator of the overall center. Professor Tunge has over 20 years of experience in organic chemistry research. In addition to the scientific expertise, both investigators have extensive experience with CoBRE administration and associated core facilities at KU.

CORE LABORATORIES

Researcher using a pipette in a laboratory

Infectious Disease Assay Development Core

Assay development and high throughput screening
Fingers typing on a laptop keyboard

Computational Chemical Biology Core

Structure and ligand based drug discovery, protein modeling, and chemoinformatics
Researcher entering data on a screen in a laboratory while being watched by a student

Synthetic Chemical Biology Core

synthesis of novel and commercially unavailable small molecules, fluorescent molecules, and peptides

Recent News

With New $11.35M NIH COBRE Award, KU Center continues fight against Infectious Diseases

The National Institutes of Health has re-upped its support of the Chemical Biology of Infectious Disease Center (CBID) at the University of Kansas with a five-year, $11.35 Phase II grant.

KU center wins $11 million grant to continue study of infectious diseases

The Chemical Biology of Infectious Disease Center at KU has been awarded an $11.35 million grant from the National Institutes of Health for phase two of the grant.

Hutchison Awarded CBID Research Project for 2021

Justin Hutchison, Assistant Professor, Department of Civil, Environmental and Architectural Engineering, University of Kansas, is the newest recipient of a CBID research project award.

Dr. Slusky, CBID graduate, develops machine learning approach better at differentiating enzyme sites

Dr. Joanna Slusky, Associate Professor of Molecular Biosciences and CBID graduate develops a machine-learning model: Metal Activity Heuristic of Metalloprotein and Enzymatic Sites.

Research reported in this website is supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Award Number P20GM113117. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.